美国医学与生物工程院会士Lijie Grace Zhang学术讲座

Integrating Advanced 3D/4D Bioprinting and Nanotechnology for Complex Tissue Regeneration

主讲人 : Dr. Lijie Grace Zhang

As an emerging tissue manufacturing technique, 3D bioprinting offers great precision and control of the internal architecture and outer shape of a scaffold, allowing for close recapitulation of complicated structures found in biological tissue. In addition, 4D bioprinting is a highly innovative additive manufacturing process to fabricate pre-designed, self-assembly structures with the ability to transform from one state to another directly off the bioprinter. The term “4D” refers to the time-dependent dynamic process triggered by specific stimulation according to predesigned requirements. However, current 3D/4D bioprinting  d additive manufacturing technologies are hindered by the lack of advanced smart “inks”. Therefore, the main  ive of our research is to develop novel biologically inspired nano or smart inks and advanced 3D/4D bioprinting techniques to fabricate the next generation of complex tissue constructs (such as vascularized tissue, neural tissue and osteochondral tissue). For this purpose, we designed and synthesized innovative biologically inspired nanomaterials (i.e., self-assembly materials, and conductive carbon nanomaterials) and smart natural materials. Through 3D/4D bioprinting in our lab, a series of biomimetic tissue scaffolds were successfully fabricated. Our results show that these bioprinted nano or smart scaffolds have not only improved mechanical properties but also excellent cytocompatibility properties for enhancing various cell growth and differentiation, thus promising for complex tissue/organ regeneration.

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主讲人简介：

Dr. Lijie Grace Zhang于布朗大学获得生物医学工程博士学位，先后在莱斯大学和哈佛医学院进行博士后工作，随后加入GW公司并担任纳米医学与组织生物工程实验室主任。Lijie Grace Zhang博士为美国医学与生物工程学会会士，曾获美国机械工程师学会Sia Nemat-Nasser Early Career Award、美国国家卫生研究院Director’s New Innovator Award、Young Innovator in Cellular and Molecular Bioengineering、美国骨骼与矿物质研究协会John Haddad Young Investigator Award、Early Career Award from the International Journal of Nanomedicine等奖项。主要科研方向包括3D/4D生物打印、纳米生物材料、组织工程、生物力学和乳腺癌骨转移。出版专著3部，发表期刊/会议论文逾125篇，获得7项发明专利授权，在学术会议、科研院所学术报告超过310次，担任Materials Science and Engineering C: Materials for Biological Applications, International Journal of Nanomedicine, ASME Journal of Engineering and Science in Medical Diagnostics and Therapy等国际期刊副主编/编辑。

Dr. Lijie Grace Zhang obtained her Ph.D. in Biomedical Engineering at Brown University. Dr. Zhang joined GW after finishing her postdoctoral training at Rice University and Harvard Medical School. She is the director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering at GW. Dr. Zhang is the Fellow of the American Institute for Medical and Biological Engineering (AIMBE). She has received the ASME Sia Nemat-Nasser Early Career Award, NIH Director’s New Innovator Award, Young Innovator in Cellular and Molecular Bioengineering, John Haddad Young Investigator Award by American Society for Bone and Mineral Research, and Early Career Award from the International Journal of Nanomedicine, etc. Her research interests include 3D/4D bioprinting, nanobiomaterials, tissue engineering, biomechanics, and breast cancer bone  stasis. Dr. Zhang has authored 3 books, over 125 journal papers, book chapters and conference proceedings, 7 patents and has presented her work on over 310 conferences, university and institutes. She also serves as the Editor of Materials Science and Engineering C: Materials for Biological Applications; Associate Editor-in-Chief of International Journal of Nanomedicine; and Associate Editor of ASME Journal of Engineering and Science in Medical Diagnostics and Therapy.